The pain you experience from Wrinkle Relaxing injections should be minimal as the needle used is very fine and only a tiny amount of substance is used. Like most injection, the point of entry may be a little painful but the treatment is very quick making it bearable. Some patients choose to take painkillers before treatment but anti-inflammatory painkillers such as ibuprofen and aspirin can thin the blood which will heighten the risk of bruising post-procedure and your doctor or nurse may advise against treating you. If you do feel you need to take a painkiller before treatment then a non-inflammatory medication like paracetamol is the safest option. You must always be honest and upfront about what medication you are on before having any treatment.